Wegener’s Granulomatosis Disease

Wegener’s granulomatosis is a sort of disease that results inflammation of the blood vessels i.e. the arteries and veins. This disease causes a huge impact on the small and medium size blood vessels in numerous body organs. Granulomatosis along with polyangiitis is a fragment of greater group of vasculictic syndromes. All the members’ syndromes of the group are characterized with an autoimmune attack which is an outcome of a circulating antibody. This antibody is considered abnormal in nature and is termed as Antineutrophil Cytoplasmic Antibodies or the ANCAs.

Basically the disease involves inflammation of arteries. The function of arteries is to supply blood to the tissues of the lungs, the kidneys and the nasal passage of a human body. However, the diseased body suffers from the incomplete form of the same that includes one of these areas. In the cases when both of the lungs and kidneys are affected together, a generalized term is utilized to refer the disease i.e. the Wegener’s granulomatosis. The disease has been usually seen affecting adults in their young or Middle Ages. However, it may also have an impact in children.


The actual causes behind Wegener’s granulomatosis are unknown to medical science yet. However, it is said that the major reason behind the disease appears to be the events that triggers an abnormal reaction in the immune system. The events are triggered due to the development of an initial inflammation.

The blend of these events can result in inflamed and constricted blood vessels. This may also outcomes in constricted blood vessels and damage causing tissue masses known as the granulomas. It is assumed that the triggering event might result in infection. However, no special kind of infection has been located as a result of it.


The symptoms of Wegener’s granulomatosis include:loss of weight, fatiguecontinuous feversbreath shortnesspains in the jointsbloody sputuminflammation in the sinusfatigue

Other symptoms that have been observed in patients suffering from Wegener’s granulomatosis are nasal ulcerations and nasal discharge filled with blood. The inflammation occurring in blood can also be sighted in the form of inflamed eyes, the nerves and the middle of the ear and also in the skin of a person. The inflammation caused in skin results in skin nodules or ulcers.


The lab examination conducted on patients suspected to be suffering from Wegener’s granulomatosis includes urine testing. This helps in the detection of protein and red blood cells present in the urine. These proteins are impossible to be spotted by naked eyes.

The other sort of test that is conducted in this regard includes the x-ray test of the chest and sinues. This test assists in the detection of abnormalities as an outcome of lung and sinus inflammation.

Other sort of test is the blood test that helps in the detection of abnormalities in inflammation. These include the sedimentation rate and the C-reactive protein. Another important blood test is brought in application for monitoring whether Wegener’s granulomatos is antineutrophil cytoplasmic antibody. It is also regarded as the ANCA test. The test is commonly conducted at the time when the disease is in active state.

The true confirmation of Wegener’s granulomatosis is obtained by analyzing both the abnormal cellular formations and the vasculits in a biopsy of the tissue which is functioning along with the inflammatory process.


It is a life threatening disease and can turn risky within a few months time. The cure for the same includes the elimination of the process of inflammation by the suppression of the immune system.

The medicines that are used for the treatment of Wegener’s granulomatosis include larger doses of cortisone and immunosuppressive drugs. Other medicnes that are helpful in this regard includes the trimethoprim or the Bactrim. It helps in the replacement of the activity of the disease in the patient who is suffering from it.

The patient is provided Cytoxan first, till the time the disease remains in the state of remission. Afterwards the patient is asked to switch the doses with prednisone, till the duration of the time when the disease remains in the state of remission. Finally the patient is made to rely upon methotrexate for a time span of two years.